ABCMdb

PMID: 10951189

Duffieux F, Annereau JP, Boucher J, Miclet E, Pamlard O, Schneider M, Stoven V, Lallemand JY
Nucleotide-binding domain 1 of cystic fibrosis transmembrane conductance regulator production of a suitable protein for structural studies.
Eur J Biochem. 2000 Sep;267(17):5306-12., [PubMed]

Sentences

No. Mutations Sentence Comment

40 ABCC7 p.Lys464Met ABCC7 p.Asp572Met Synthetic mutated oligonucleotides (Eurogentec) were K464M: 5H -CCACTGGAGCAGGCATGA- CTTCACTTCTAATGGTG-3H and D572M: 5H -GCTGATTTGT- ATTTATTAATGTCTCCTTTTGGATACC-3H , where underlined nucleotides represent mutations. Login to comment 116 ABCC7 p.Lys464Met ABCC7 p.Asp572Met Mutations were introduced in the Walker A and B motifs (K464M, D572M), at positions known to be involved in ATP binding and hydrolysis [21]. Login to comment 340 ABCC7 p.Gly551Asp & Cohn, J.A. (2000) ATP hydrolysis by a CFTR domain: pharmacology and effects of G551D mutation. Login to comment