PMID: 10918483

Hyde SC, Southern KW, Gileadi U, Fitzjohn EM, Mofford KA, Waddell BE, Gooi HC, Goddard CA, Hannavy K, Smyth SE, Egan JJ, Sorgi FL, Huang L, Cuthbert AW, Evans MJ, Colledge WH, Higgins CF, Webb AK, Gill DR
Repeat administration of DNA/liposomes to the nasal epithelium of patients with cystic fibrosis.
Gene Ther. 2000 Jul;7(13):1156-65., [PubMed]
Sentences
No. Mutations Sentence Comment
24 ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 10918483:24:403
status: NEW
view ABCC7 p.Gly551Asp details
ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 10918483:24:492
status: NEW
view ABCC7 p.Gly551Asp details
ABCC7 p.Gly542*
X
ABCC7 p.Gly542* 10918483:24:168
status: NEW
view ABCC7 p.Gly542* details
 Genotype Dose Sex Age (years) FEV1 (litres) Clinical score A1 ⌬F508/1078delT CFTR M 22.7 3.25 85 A2 ⌬F508/⌬F508 CFTR M 22.9 3.4 90 A3 ⌬F508/G542X CFTR M 28.5 1.75 70 A5 ⌬F508/F945L CFTR M 30.3 3.05 70 A6 ⌬F508/⌬F508 CFTR M 24.4 1.25 70 B1 ⌬F508/⌬F508 CFTR M 17.6 3.8 90 B3 ⌬F508/1898+1(GϾA) CFTR F 16.9 2.15 80 B4 ⌬F508/G551D CFTR M 32.8 1.8 55 B6 ⌬F508/⌬F508 CFTR M 18.8 3.5 95 A4 ⌬F508/G551D Placebo F 16.5 2.65 95 B5 ⌬F508/3659delC Placebo M 16.4 2.8 85 All patients were pancreatic insufficient. Login to comment