PMID: 10898722

Luo J, Zhu T, Evagelidis A, Pato MD, Hanrahan JW
Role of protein phosphatases in the activation of CFTR (ABCC7) by genistein and bromotetramisole.
Am J Physiol Cell Physiol. 2000 Jul;279(1):C108-19., [PubMed]
Sentences
No. Mutations Sentence Comment
198 ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 10898722:198:202
status: NEW
view ABCC7 p.Gly551Asp details
 Data are means Ϯ SE; n ϭ 4 experiments. C GENISTEIN, BROMOTETRAMISOLE, AND DEPHOSPHORYLATION OF CFTR a deletion of phenylalanine 508 (21), whereas Br-t activates several mutants, including G551D, when cells have only basal PKA activity (4). Login to comment 256 ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 10898722:256:160
status: NEW
view ABCC7 p.Gly551Asp details
 In previous work, we found that (-)-Br-t inhibits CFTR rundown in patches from CHO and human airway epithelial cells [NP34 (4, 5)] and also activates quiescent G551D mutant channels that are normally unresponsive to forskolin. Login to comment