PMID: 10893240

Matsuo M, Tanabe K, Kioka N, Amachi T, Ueda K
Different binding properties and affinities for ATP and ADP among sulfonylurea receptor subtypes, SUR1, SUR2A, and SUR2B.
J Biol Chem. 2000 Sep 15;275(37):28757-63., [PubMed]
Sentences
No. Mutations Sentence Comment
105 ABCC8 p.Arg1420Cys
X
ABCC8 p.Arg1420Cys 10893240:105:273
status: NEW
view ABCC8 p.Arg1420Cys details
 Cooperative Binding of Nucleotides to NBF1 and NBF2-We reported previously that ADP stabilizes the binding of prebound 8-azido-[32 P]ATP at NBF1 on SUR1, either by direct binding to NBF2 or hydrolysis of bound ATP at NBF2 (21), and this effect was impaired in mutant SUR1 (R1420C) found in Japanese persistent hyperinsulinemic hypoglycemia of infancy patients (24). Login to comment