PMID: 10866047

Macfarlane WM, O'Brien RE, Barnes PD, Shepherd RM, Cosgrove KE, Lindley KJ, Aynsley-Green A, James RF, Docherty K, Dunne MJ
Sulfonylurea receptor 1 and Kir6.2 expression in the novel human insulin-secreting cell line NES2Y.
Diabetes. 2000 Jun;49(6):953-60., [PubMed]
Sentences
No. Mutations Sentence Comment
188 ABCC8 p.Val187Asp
X
ABCC8 p.Val187Asp 10866047:188:54
status: NEW
view ABCC8 p.Val187Asp details
 Indeed, recent studies have demonstrated that even as V187D-SUR1 mutations in PHHI beta-cells led to the appearance of KATP channels in patient tissue, expression of the same mutation in Xenopus oocytes failed to reconstitute the channels (8). Login to comment 189 ABCC8 p.Val187Asp
X
ABCC8 p.Val187Asp 10866047:189:54
status: NEW
view ABCC8 p.Val187Asp details
 Indeed, recent studies have demonstrated that even as V187D-SUR1 mutations in PHHI b-cells led to the appearance of KATP channels in patient tissue, expression of the same mutation in Xenopus oocytes failed to reconstitute the channels (8). Login to comment