PMID: 10806188

Loo TW, Clarke DM
Drug-stimulated ATPase activity of human P-glycoprotein is blocked by disulfide cross-linking between the nucleotide-binding sites.
J Biol Chem. 2000 Jun 30;275(26):19435-8., [PubMed]
Sentences
No. Mutations Sentence Comment
84 ABCB4 p.Ser1071Cys
X
ABCB4 p.Ser1071Cys 10806188:84:107
status: NEW
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ABCB4 p.Leu1082Cys
X
ABCB4 p.Leu1082Cys 10806188:84:304
status: NEW
view ABCB4 p.Leu1082Cys details
ABCB4 p.Gly432Cys
X
ABCB4 p.Gly432Cys 10806188:84:171
status: NEW
view ABCB4 p.Gly432Cys details
ABCB4 p.Val1079Cys
X
ABCB4 p.Val1079Cys 10806188:84:247
status: NEW
view ABCB4 p.Val1079Cys details
 Residue in NBD1 Cys-1074 Residue in NBD2 Cys-431 L425C -a V426C - V1069C - G427C ϩb G1070C - N428C - S1071C - S429C - S1072C - G430C - G1073C - Cys-431 - Cys-1074 - G432C - G1075C - K433C - K1076C - S434C - S1077C - T435C - T1078C - T436C - V1079C - V437C - V1080C - Q438C - Q1081C - L439C ϩ L1082C NDc a ϩ, cross-linked product not detected on SDS-PAGE. Login to comment