PMID: 10736180

Chen EY, Bartlett MC, Clarke DM
Cystic fibrosis transmembrane conductance regulator has an altered structure when its maturation is inhibited.
Biochemistry. 2000 Apr 4;39(13):3797-803., 2000-04-04 [PubMed]
Sentences
No. Mutations Sentence Comment
199 ABCC7 p.Arg297Gln
X
ABCC7 p.Arg297Gln 10736180:199:0
status: NEW
view ABCC7 p.Arg297Gln details
 R297Q, which shows a similar level of maturation as the wild-type CFTR, showed CFTR-like channel activity. Login to comment 200 ABCC7 p.His949Tyr
X
ABCC7 p.His949Tyr 10736180:200:0
status: NEW
view ABCC7 p.His949Tyr details
 H949Y is a partially processing-defective mutant that expressed less than 10% of the mature band, relative to wild type (3). Login to comment 202 ABCC7 p.Gly149Arg
X
ABCC7 p.Gly149Arg 10736180:202:0
status: NEW
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 G149R, like ∆F508, is a processing mutant with no detectable mature CFTR protein. Login to comment 224 ABCC7 p.Gly149Arg
X
ABCC7 p.Gly149Arg 10736180:224:124
status: NEW
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ABCC7 p.His949Tyr
X
ABCC7 p.His949Tyr 10736180:224:113
status: NEW
view ABCC7 p.His949Tyr details
ABCC7 p.Arg297Gln
X
ABCC7 p.Arg297Gln 10736180:224:106
status: NEW
view ABCC7 p.Arg297Gln details
 Membranes were prepared from HEK cells transiently transfected with various CFTR cDNAs: WT, ∆F508, R297Q, H949Y, and G149R. Login to comment