ABCMdb

PMID: 10720935

Skach WR
Defects in processing and trafficking of the cystic fibrosis transmembrane conductance regulator.
Kidney Int. 2000 Mar;57(3):825-31., [PubMed]

Sentences

No. Mutations Sentence Comment

52 ABCC7 p.Gly85Glu ABCC7 p.Gly91Arg The post-translational pathway is utilized by most (Ͼ60%) of WT chains and essentially all G85E and G91R mutant chains. Login to comment 76 ABCC7 p.Gly85Glu ABCC7 p.Gly91Arg While it is often tempting Two CF mutations, G85E and G91R, each introduce to view the acquisition of protein function as a criteria an additional charged residue within the hydrophobic for "normal" folding, in the case of CFTR this is not core of TM1. Login to comment 79 ABCC7 p.Gly85Glu ABCC7 p.Gly91Arg This suggested that G85E and G91R CFTR mutants [35]. Login to comment 93 ABCC7 p.Gly85Glu In addition, they indicated that G85E and Golgi and lysosome-independent compartment. Login to comment