PMID: 10581361

Seibert FS, Chang XB, Aleksandrov AA, Clarke DM, Hanrahan JW, Riordan JR
Influence of phosphorylation by protein kinase A on CFTR at the cell surface and endoplasmic reticulum.
Biochim Biophys Acta. 1999 Dec 6;1461(2):275-83., [PubMed]
Sentences
No. Mutations Sentence Comment
415 ABCC7 p.Ser753Arg
X
ABCC7 p.Ser753Arg 10581361:415:41
status: NEW
view ABCC7 p.Ser753Arg details
 The 5.8 kDa fragment from all except the S753R version could still be phosphorylated by PKA. Login to comment 416 ABCC7 p.Ser753Arg
X
ABCC7 p.Ser753Arg 10581361:416:126
status: NEW
view ABCC7 p.Ser753Arg details
 When tested in both e&#a5;ux experiments and by patch-clamping the chloride channel response to PKA of cells expressing 11SA- S753R was reduced a further 40% compared to the 10SA. Login to comment