PMID: 10542444

Hwang TC, Sheppard DN
Molecular pharmacology of the CFTR Cl- channel.
Trends Pharmacol Sci. 1999 Nov;20(11):448-53., [PubMed]
Sentences
No. Mutations Sentence Comment
102 ABCC7 p.Thr1134Phe
X
ABCC7 p.Thr1134Phe 10542444:102:171
status: NEW
view ABCC7 p.Thr1134Phe details
 Interestingly, the DPC-binding site could be transferred from Ser341 to Ser1141 in M12 by simultaneously mutating residues in M6 and M12, whereas another mutation in M12, Thr1134Phe, increased the affinity of DPC block, but decreased single-channel conductance37. Login to comment 104 ABCC7 p.Thr1134Phe
X
ABCC7 p.Thr1134Phe 10542444:104:194
status: NEW
view ABCC7 p.Thr1134Phe details
 They speculatedthatthehydroxylside-chainofSer341probably interacts with the carboxyl moiety of DPC via hydrogen bonding, and that this interaction is stabilized by the phenyl ring of the mutant Thr1134Phe interacting with the second phenyl ring of DPC (for a molecular model of MSD1 R MSD2 NBD1 NBD2 P P P ATP G O C O C O C ATP ATP ADP +Pi ADP +Pi ATP ADP +Pi Cl- Cl- Cl- PKA PP2A PKA PP2C trends in Pharmacological Sciences Fig. 3. Login to comment