PMID: 10498902

Soufir N, Moles JP, Vilmer C, Moch C, Verola O, Rivet J, Tesniere A, Dubertret L, Basset-Seguin N
P16 UV mutations in human skin epithelial tumors.
Oncogene. 1999 Sep 23;18(39):5477-81., [PubMed]
Sentences
No. Mutations Sentence Comment
85 ABCC8 p.Arg248Trp
X
ABCC8 p.Arg248Trp 10498902:85:635
status: NEW
view ABCC8 p.Arg248Trp details
 Mutations in samples 79, 121, 132 and 153 are predicted to be UVB induced mutations Table 2 P53 gene mutations characterized in human skin epithelial tumors Tumor size Exon Mutation Codon modi®cation Squamous lesions AK 241 SSC 350 Exon 8 Exon 7 gtcCtgg?gtcTcgg ggcGgc?ggcTgca Pro278Leu gly245Cys Basal cell carcinomas BCC 353 BCC 274 BCC 354 BCC 352 BCC 274 BCC 354 BCC 351 BCC 355 Exon 5 Exon 6 Exon 6 Exon 6 Exon 6 Exon 7 Exon 7 Exon 8 gccCCca?gccTTca tcgAcat?tcgGcat tcgAcat?cgGcat atcCgagt?atcTgagt cctAtga?cctGtga gttCctg?gttTctg aacCgga?aacTgga ctcCgcaa?ctcTcaa Pro177Leu Arg213Arg Arg213Arg Arg196Stop Tyr220Cys Ser241Phe Arg248Trp Arg 290 frameshift* *Indicates mutations which have not previously been described in the IARC p53 database 49 tumors (8/20 SCCs, three of which harbouring a p16 mutation; 7/28 BCC, one having a p16 mutation) (data not shown). Login to comment