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PMID: 10419835
Shen BQ, Widdicomb JH, Mrsny RJ
Hepatocyte growth factor inhibits amiloride-sensitive Na(+) channel function in cystic fibrosis airway epithelium in vitro.
Pulm Pharmacol Ther. 1999;12(3):157-64.,
[PubMed]
Sentences
No.
Mutations
Sentence
Comment
34
ABCC7 p.Arg117His
X
ABCC7 p.Arg117His 10419835:34:187
status:
NEW
view ABCC7 p.Arg117His details
Amiloride, which has been shown to MATERIALS AND METHODS inhibit the transport of Na+ ions by ENaC, has been shown to inhibit the baseline absorption of Na+ and CF bronchial cells (DF508/
R117H
and DF508/DF508 genotype) were isolated by protease digestion from fluid by >80%.4,9,10 Further, ENaC activity appears to be overexpressed in CF airway epithelial cells, tissues obtained surgically from CF patients.
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