PMID: 10388000

Fine RL, Chambers TC, Sachs CW
P-Glycoprotein, Multidrug Resistance and Protein Kinase C.
Oncologist. 1996;1(4):261-268., [PubMed]
Sentences
No. Mutations Sentence Comment
96 ABCB1 p.Ser671Asn
X
ABCB1 p.Ser671Asn 10388000:96:12
status: NEW
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 Mutation of serine 671 to asparagine in the linker region of P-glycoprotein abrogated verapamil and PKC-α-stimulated ATPase activity. Login to comment 141 ABCB1 p.Gly185Val
X
ABCB1 p.Gly185Val 10388000:141:61
status: NEW
view ABCB1 p.Gly185Val details
 The human MDR1 P-glycoprotein, with a mutation of amino acid glycine 185 to valine, was also expressed in Sf9 cells and used as membrane vesicles. Login to comment