ABCMdb

PMID: 10354464

Chabot H, Vives MF, Dagenais A, Grygorczyk C, Berthiaume Y, Grygorczyk R
Downregulation of epithelial sodium channel (ENaC) by CFTR co-expressed in Xenopus oocytes is independent of Cl- conductance.
J Membr Biol. 1999 Jun 1;169(3):175-88., 1999-06-01 [PubMed]

Sentences

No. Mutations Sentence Comment

31 ABCC7 p.Gly551Asp ABCC7 p.Arg117His This hypothesis was based on the observation that the magnitude of Iamil downregulation was correlated with the ability of CFTR to conduct Cl- , was reduced for CFTR mutants that had diminished membrane Cl- permeability (G551D, ⌬F508, R117H) and was abolished by inhibition of CFTR Cl-conductance using diphenylamine-carboxylate (DPC; Mall et al., 1996; Briel et al., 1998). Login to comment 255 ABCC7 p.Gly551Asp ABCC7 p.Gly551Asp ABCC7 p.Gly551Asp The interaction was not observed if the CFTR peptide fragment contained the CF mutation G551D, and coexpression of ENaC with each CFTR peptide fragment in Xenopus oocytes suggested that ENaC was downregulated by wild type but not G551D peptide. Login to comment