PMID: 10206998

Schreiber R, Nitschke R, Greger R, Kunzelmann K
The cystic fibrosis transmembrane conductance regulator activates aquaporin 3 in airway epithelial cells.
J Biol Chem. 1999 Apr 23;274(17):11811-6., 1999-04-23 [PubMed]
Sentences
No. Mutations Sentence Comment
60 ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 10206998:60:82
status: NEW
view ABCC7 p.Gly551Asp details
 Oocytes of identical batches were injected with 10-50 ng of cRNA (wild-type CFTR, G551D-CFTR, and hAQP3 cloned from human airway cells). Login to comment 130 ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 10206998:130:57
status: NEW
view ABCC7 p.Gly551Asp details
 A mutation in the first nucleotide-binding fold of CFTR (G551D-CFTR) abolished the effects of IBMX on Pf (Fig. 6B), confirming impaired regulation of hAQP3 by mutant forms of CFTR. Login to comment 175 ABCC7 p.Gly551Asp
X
ABCC7 p.Gly551Asp 10206998:175:123
status: NEW
view ABCC7 p.Gly551Asp details
 Pf was increased in AQP3/CFTR-coexpressing oocytes and was further enhanced by IBMX, whereas oocytes coexpressing AQP3 and G551D-CFTR did not show an increase in Pf upon stimulation by IBMX. Login to comment