ABCMdb

PMID: 10099692

Seino S
ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies.
Annu Rev Physiol. 1999;61:337-62., [PubMed]

Sentences

No. Mutations Sentence Comment

204 ABCC8 p.Lys719Ala ABCC8 p.Lys1384Met However, mutations of lysine residues in the Walker A motifs in NBF-1 (K719A) and/or the equivalent mutation in NBF-2 (K1384M) of SUR1 do not prevent channel inhibition by ATP (36). Login to comment 205 ABCC1 p.Gln834His Mutations in the linker region between the Walker A motif and the Walker B motif of NBF-1 (G827D, G827R, and Q834H), the equivalent mutations in NBF-2 (G1479D, G1479R, G1485D, G1485R, Q1486H), or the mutation of Walker B motif of NBF-2 (D1506A) do not abolish channel inhibition by ATP (105). Login to comment 207 ABCC8 p.Lys719Ala ABCC8 p.Lys1384Met In contrast, neither the NBF-1 mutant K719A channel nor the NBF-2 mutant K1384M channel is activated by MgADP (36). Login to comment 210 ABCC8 p.Lys719Ala ABCC8 p.Lys1384Met A mutation in the Walker A motif in NBF-1 (K719A) abolishes channel activation by diazoxide, but a mutation in the Walker A motif in NBF-2 (K1384M) does not affect the channel activation (36). Login to comment 211 ABCC1 p.Gln834His Mutations in the linker region and the Walker B motif of NBF-2 (G1479D, G1479R, G1485D, G1485R, Q1486H, and D1506A) abolish channel activation by diazoxide, and mutations in the linker region of NBF-1 (G827D, G827R, and Q834H) alter the kinetics of diazoxide activation (106). Login to comment 230 ABCC8 p.Asp854Asn ABCC8 p.Lys719Arg ABCC8 p.Lys719Met Both mutations of the lysine in the Walker A motif (K719R, K719M) and a mutation of the aspartic acid in the Walker B motif (D854N) of SUR1 impair Mg2+ -independent high-affinity ATP binding (124). Login to comment