ABCC1 p.Pro14Ala
| Predicted by SNAP2: | A: N (66%), C: N (66%), D: N (57%), E: N (57%), F: D (66%), G: N (57%), H: N (57%), I: D (53%), K: N (61%), L: D (53%), M: D (59%), N: N (72%), Q: N (78%), R: N (53%), S: N (72%), T: N (61%), V: N (53%), W: D (80%), Y: D (53%), |
| Predicted by PROVEAN: | A: N, C: N, D: N, E: N, F: N, G: N, H: N, I: N, K: N, L: N, M: N, N: N, Q: N, R: N, S: N, T: N, V: N, W: N, Y: N, |
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[hide] A melittin-related peptide from the skin of the Ja... Biochem Biophys Res Commun. 2003 Jun 27;306(2):496-500. Conlon JM, Sonnevend A, Patel M, Camasamudram V, Nowotny N, Zilahi E, Iwamuro S, Nielsen PF, Pal T
A melittin-related peptide from the skin of the Japanese frog, Rana tagoi, with antimicrobial and cytolytic properties.
Biochem Biophys Res Commun. 2003 Jun 27;306(2):496-500., [PMID:12804591]
Abstract [show]
Two peptides with antimicrobial and cytolytic properties were purified from an extract of the skin of Tago's brown frog Rana tagoi. The primary structure of one peptide (FLPILGKLLS(10)GIL.NH(2)) identifies it as a member of the temporin family, whereas the second peptide (AIGSILGALA(10)KGLPTLISWI(20)KNR.NH(2)) displays 78% sequence identity to melittin from the venom of the honeybee Apis florea. Compared with melittin, the melittin-related peptide (MRP) was equipotent in inhibiting the growth of the Gram-positive bacterium Staphylococcus aureus, 5-fold less potent against the Gram-negative bacterium Escherichia coli and against the fungal pathogen, Candida albicans. MRP was 13-fold less hemolytic than melittin against human erythrocytes and 4- and 5-fold less cytolytic against mouse EL4 T-lymphoma-derived cells and L929 fibroblasts, respectively. However, at non-cytotoxic concentrations (<or=8 microM), MRP did not protect HeLa cells from cell death produced by human rhinovirus type 2 infection.
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No. Sentence Comment
108 Conversely, substitutions that led to an increase in overall a-helicity, such as replacements of Pro14 by Ala [35] and the residues in the hinge region by Leu [3], led to an increase in activity.
X
ABCC1 p.Pro14Ala 12804591:108:97
status: NEW109 Conversely, substitutions that led to an increase in overall a-helicity, such as replacements of Pro14 by Ala [35] and the residues in the hinge region by Leu [3], led to an increase in activity.
X
ABCC1 p.Pro14Ala 12804591:109:97
status: NEW