ABCC2 p.Trp1254Phe

Predicted by SNAP2: A: D (95%), C: D (95%), D: D (95%), E: D (95%), F: D (80%), G: D (95%), H: D (95%), I: D (95%), K: D (95%), L: D (91%), M: D (91%), N: D (95%), P: D (95%), Q: D (95%), R: D (95%), S: D (95%), T: D (95%), V: D (95%), Y: D (91%),
Predicted by PROVEAN: A: D, C: D, D: D, E: D, F: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, S: D, T: D, V: D, Y: D,

[switch to compact view]
Comments [show]
Publications
[hide] Jemnitz K, Heredi-Szabo K, Janossy J, Ioja E, Vereczkey L, Krajcsi P
ABCC2/Abcc2: a multispecific transporter with dominant excretory functions.
Drug Metab Rev. 2010 Aug;42(3):402-36., [PMID:20082599]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Gerk PM, Li W, Vore M
Estradiol 3-glucuronide is transported by the multidrug resistance-associated protein 2 but does not activate the allosteric site bound by estradiol 17-glucuronide.
Drug Metab Dispos. 2004 Oct;32(10):1139-45. Epub 2004 Jul 27., [PMID:15280218]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Suzuki H, Sugiyama Y
Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): its impact on drug disposition.
Adv Drug Deliv Rev. 2002 Nov 18;54(10):1311-31., [PMID:12406647]

Abstract [show]
Comments [show]
Sentences [show]

[hide] Ito K, Oleschuk CJ, Westlake C, Vasa MZ, Deeley RG, Cole SP
Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity.
J Biol Chem. 2001 Oct 12;276(41):38108-14. Epub 2001 Aug 10., [PMID:11500505]

Abstract [show]
Comments [show]
Sentences [show]