ABCC8 p.Asp18Gly
| Predicted by SNAP2: | A: N (61%), C: N (72%), E: N (87%), F: D (63%), G: N (57%), H: N (53%), I: D (59%), K: N (72%), L: D (59%), M: D (53%), N: N (87%), P: D (63%), Q: N (72%), R: N (57%), S: N (87%), T: N (93%), V: N (61%), W: D (80%), Y: D (59%), |
| Predicted by PROVEAN: | A: N, C: N, E: N, F: N, G: N, H: N, I: N, K: N, L: N, M: N, N: N, P: N, Q: N, R: N, S: N, T: N, V: N, W: N, Y: N, |
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[hide] Cloning and sequence analysis of cDNAs encoding pr... J Biol Chem. 1993 Feb 15;268(5):3052-5. Ducancel F, Matre V, Dupont C, Lajeunesse E, Wollberg Z, Bdolah A, Kochva E, Boulain JC, Menez A
Cloning and sequence analysis of cDNAs encoding precursors of sarafotoxins. Evidence for an unusual "rosary-type" organization.
J Biol Chem. 1993 Feb 15;268(5):3052-5., [PMID:8428983]
Abstract [show]
Sarafotoxins (SRTXs) are 21-amino acid peptides structurally and functionally similar to endothelins (ETs). To understand how SRTXs are overproduced in venom glands of the snakes Atractaspis engaddensis and hence used as toxins, we cloned cDNAs encoding SRTXs and elucidated their nucleotide sequences. We predict that SRTX precursors are large prepropolypeptide chains with an unusual "rosary-type" structure made of 12 successive similar stretches of 40 residues (39 in the first stretch). Each stretch begins with a "spacer" of 19 invariant residues (18 in the first stretch) immediately followed by the sequence of one SRTX isoform. Six different isoforms are identified within a single precursor molecule. Maturation of the precursor may require endopeptidases that cleave the Leu-Cys bond and the Trp-Arg/Lys bond invariably found at the SRTX N and C termini, respectively.
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No. Sentence Comment
73 We called (i) SRTX-a1 an isoform of SRTX-a in which a Serreplaces a Thr at position +7 (these two isoforms were found in each of the 14 clones); (ii) SRTX-e anisoform of SRTX-d in which a Gly replaces Asp at position 18 (Fig. 3).
X
ABCC8 p.Asp18Gly 8428983:73:188
status: NEW