ABCC8 p.Gly251Asp
| Predicted by SNAP2: | A: N (66%), C: N (66%), D: N (66%), E: N (66%), F: N (53%), H: N (78%), I: N (57%), K: N (53%), L: N (61%), M: D (59%), N: N (87%), P: N (53%), Q: N (78%), R: N (53%), S: N (87%), T: N (66%), V: N (66%), W: N (53%), Y: N (53%), |
| Predicted by PROVEAN: | A: D, C: D, D: D, E: D, F: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, S: D, T: D, V: D, W: D, Y: D, |
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[hide] A pathogenic cytochrome b mutation reveals new int... J Biol Chem. 2002 Dec 20;277(51):49397-402. Epub 2002 Oct 15. Saint-Georges Y, Bonnefoy N, di Rago JP, Chiron S, Dujardin G
A pathogenic cytochrome b mutation reveals new interactions between subunits of the mitochondrial bc1 complex.
J Biol Chem. 2002 Dec 20;277(51):49397-402. Epub 2002 Oct 15., [PMID:12384503]
Abstract [show]
Energy transduction in mitochondria involves five oligomeric complexes embedded within the inner membrane. They are composed of catalytic and noncatalytic subunits, the role of these latter proteins often being difficult to assign. One of these complexes, the bc1 complex, is composed of three catalytic subunits including cytochrome b and seven or eight noncatalytic subunits. Recently, several mutations in the human cytochrome b gene have been linked to various diseases. We have studied in detail the effects of a cardiomyopathy generating mutation G252D in yeast. This mutation disturbs the biogenesis of the bc1 complex at 36 degrees C and decreases the steady-state level of the noncatalytic subunit Qcr9p. In addition, the G252D mutation and the deletion of QCR9 show synergetic defects that can be partially bypassed by suppressor mutations at position 252 and by a new cytochrome b mutation, P174T. Altogether, our results suggest that the supernumerary subunit Qcr9p enhances or stabilizes the interactions between the catalytic subunits, this role being essential at high temperature.
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No. Sentence Comment
28 In particular, one mutation that substitutes a glycine by an aspartate residue at position 251 of cytochrome b (G251D) is associated with a histiocytoid cardiomyopathy (16, 17).
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ABCC8 p.Gly251Asp 12384503:28:112
status: NEW