ABCC8 p.Tyr179Ala

Predicted by SNAP2: A: D (59%), C: D (63%), D: D (59%), E: D (75%), F: D (66%), G: N (53%), H: D (63%), I: D (71%), K: D (71%), L: D (71%), M: D (71%), N: N (61%), P: D (75%), Q: D (63%), R: D (80%), S: N (53%), T: D (59%), V: D (66%), W: D (75%),
Predicted by PROVEAN: A: D, C: D, D: D, E: D, F: N, G: D, H: N, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, S: D, T: D, V: D, W: D,

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[hide] Jacobson MA, Kreatsoulas C, Pascarella DM, O'Brien JA, Sur C
The M1 muscarinic receptor allosteric agonists AC-42 and 1-[1'-(2-methylbenzyl)-1,4'-bipiperidin-4-yl]-1,3-dihydro-2H-benzimidazol-2-one bind to a unique site distinct from the acetylcholine orthosteric site.
Mol Pharmacol. 2010 Oct;78(4):648-57. Epub 2010 Jul 21., [PMID:20660086]

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