ABCC1 p.Glu535Ala

Predicted by SNAP2: A: D (71%), C: D (71%), D: D (75%), F: D (85%), G: D (75%), H: D (80%), I: D (85%), K: D (91%), L: D (80%), M: D (80%), N: D (75%), P: D (91%), Q: D (75%), R: D (91%), S: D (80%), T: D (80%), V: D (75%), W: D (91%), Y: D (80%),
Predicted by PROVEAN: A: D, C: D, D: D, F: D, G: D, H: D, I: D, K: D, L: D, M: D, N: D, P: D, Q: D, R: D, S: D, T: D, V: D, W: D, Y: D,

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[hide] Iram SH, Cole SP
Expression and function of human MRP1 (ABCC1) is dependent on amino acids in cytoplasmic loop 5 and its interface with nucleotide binding domain 2.
J Biol Chem. 2011 Mar 4;286(9):7202-13. Epub 2010 Dec 20., 2011-03-04 [PMID:21177244]

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[hide] Iram SH, Cole SP
Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1).
J Biol Chem. 2012 Mar 2;287(10):7543-55. Epub 2012 Jan 9., [PMID:22232552]

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[hide] Iram SH, Cole SP
Differential functional rescue of Lys(513) and Lys(516) processing mutants of MRP1 (ABCC1) by chemical chaperones reveals different domain-domain interactions of the transporter.
Biochim Biophys Acta. 2014 Mar;1838(3):756-65. doi: 10.1016/j.bbamem.2013.11.002. Epub 2013 Nov 11., [PMID:24231430]

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