ABCMdb

ABCC7 p.Gln1291Gly

None has been submitted yet.

Publications

PMID: 25887396 [PubMed] Dong Q et al: "Mutating the Conserved Q-loop Glutamine 1291 Selectively Disrupts Adenylate Kinase-dependent Channel Gating of the ATP-binding Cassette (ABC) Adenylate Kinase Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) and Reduces Channel Function in Primary Human Airway Epithelia."

No. Sentence Comment

142 Gln mutations that resulted in shortening (Q1291A) or deletion (Q1291G) of the side chain reduced Ap5A inhibition (Fig. 3, A FIGURE 1. Login to comment
154 To further evaluate the effect of these mutations, we tested inhibition of Q1291G CFTR current with a range of ApA concentrations. Login to comment
181 No significant differences were detected between bars 1, 3, 4, 5, 6, 7, and 8 (one-way ANOVA followed by Holm-Sidak`s method of all pairwise multiple comparisons; wild-type CFTR, n afd; 13; F508del CFTR, n afd; 10; Q1291A CFTR, n afd; 4; Q1291G CFTR, n afd; 4; Q1291F CFTR, n afd; 6; Q1291H CFTR, n afd; 6; Q1291W CFTR, n afd; 6; Q1291Y CFTR, n afd; 6). Login to comment
189 *, p b0d; 0.01 when compared with bar 1, 3, 4, 5, 6, or 7 (one-way ANOVA followed by Holm-Sidak`s method of multiple comparisons versus control group; wild-type CFTR, n afd; 6; F508del CFTR, n afd; 4; Q1291G CFTR, n afd; 4; Q1291F CFTR, n afd; 6; Q1291HCFTR,nafd;4;Q1291WCFTR,nafd;4;Q1291YCFTR,nafd;4).Nosignificantdifferencesweredetectedbetweenbars1,3,4,5,6,and7(one-wayANOVA).Error bars, S.E. Selective Disruption of Adenylate Kinase-coupled CFTR Gating 14144 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME 290ߦNUMBER 22ߦMAY 29, 2015 To further probe ATPase-dependent gating of Q1291F CFTR, we studied the effect of adenosine 5b18;-(beta,ॹ-imido)triphosphate (AMPPNP). Login to comment
196 *, p b0d; 0.05 compared with wild type; double daggers, p b0d; 0.001 compared with Q1291G (one-way ANOVA followed by Holm-Sidak`s method of multiple comparisons versus control group). Login to comment
241 If the Gln-1291 side chain interacted with AMP as predicted based on the SMC-NBD structure (Fig. 1) (19), then removal of this side chain (Q1291G mutation) should affect the interaction of AMP with CFTR. Login to comment
284 D, removal of the Gln-1291 side chain (Q1291G mutation) reduces the potency of AMP to increase CFTR Clafa; current. Login to comment
316 Columns show the means afe; S.E. (error bars) of 15 (wild type), 11 (Q1291F mutant), and 5 (Q1291G mutant) individual experiments obtained from two (wild type) and three (Q1291F and Q1291G mutants) membrane patches. Login to comment