ABCC7 p.Gly551Lys
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PMID: 25225552
[PubMed]
Lin WY et al: "A single amino acid substitution in CFTR converts ATP to an inhibitory ligand."
No.
Sentence
Comment
21
G551E, but not G551K or G551S, exhibits a similar phenotype, indicating that electrostatic repulsion between the negatively charged side chain of aspartate and the &#e067;-phosphate of ATP accounts for the observed mutational effects.
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ABCC7 p.Gly551Lys 25225552:21:15
status: NEW32 Because this inhibitory effect is observed also in G551E, but not in G551K or G551S, a basic chemical mechanism of an electrostatic repulsion between the negatively charged side chain of 551D/E and the &#e067;-phosphate of ATP in shaping the observed mutational effects is proposed.
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ABCC7 p.Gly551Lys 25225552:32:69
status: NEW162 With a neutral (G551S) or cationic (G551K) side chain at residue 551, the channels respond to ATP in a manner similar to that of WT-CFTR.
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ABCC7 p.Gly551Lys 25225552:162:36
status: NEW191 (A-C) Responses to ATP withdrawal in different G551 mutants: G551S (A), G551K (B), and G551E (C).
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ABCC7 p.Gly551Lys 25225552:191:72
status: NEW