ABCC7 p.Lys1060Cys
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PMID: 25190805
[PubMed]
Wang W et al: "An electrostatic interaction at the tetrahelix bundle promotes phosphorylation-dependent cystic fibrosis transmembrane conductance regulator (CFTR) channel opening."
No.
Sentence
Comment
127
As we showed in Fig. 2 the single E267C and K1060C mutations reduced CFTR channel activity especially after PKI addition but not to the extent of the charge-reversal substitutions.
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ABCC7 p.Lys1060Cys 25190805:127:44
status: NEW129 Conversely, the same positively charged reagent modestly increased the current mediated by K1060C-CFTR; an effect that also was reversed by DTT (Fig. 4B; mean data in Fig. 4C).
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ABCC7 p.Lys1060Cys 25190805:129:91
status: NEW212 A positively charged thiol modifier strongly inhibits E267C-CFTR currents in an activity-dependent manner but modestly stimulates K1060C-CFTR currents.
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ABCC7 p.Lys1060Cys 25190805:212:130
status: NEW215 B, corresponding K1060C-CFTR macropatch record showing modest stimulation of this cysteine mutant by MTSET that also was reversed by subsequent DTT addition.
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ABCC7 p.Lys1060Cys 25190805:215:17
status: NEW