ABCC7 p.Ile1112Cys
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PMID: 23955087
[PubMed]
Wang W et al: "Relative contribution of different transmembrane segments to the CFTR chloride channel pore."
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Sentence
Comment
77
Note that while MTSES caused rapid inhibition of macroscopic current amplitude in T1115C and S1118C, inhibition of I1112C current was much slower (note different time scale for this mutant).
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ABCC7 p.Ile1112Cys 23955087:77:115
status: NEW104 Black bars represent a significant difference from cys-less (P<0.05); gray bars (I1112C only) no significant difference. Mean of data from three to six patches Results Accessibility of cysteine side chains introduced into TMs 5, 7, and 11 We hypothesized that the central portion of the CFTR pore might be lined by TMs 1, 5, 6, 7, 11, and 12 (Fig. 1).
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ABCC7 p.Ile1112Cys 23955087:104:81
status: NEW117 Application of MTSES (200 bc;M) following channel activation with PKA and ATP caused a decrease in macroscopic current amplitude in I1112C, T1115C and S1118C, but not in T1121C (Fig. 2a, b) or in I1109C, F1110C, F1111C, A1113C, V1114C, F1116C, or I1117C (Fig. 2c).
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ABCC7 p.Ile1112Cys 23955087:117:135
status: NEW123 Figure 3 confirms that application of external MTSES (200 bc;M) following channel activation with cAMP-stimulatory cocktail caused a decrease in whole cell current amplitude in T1115C, S1118C, and T1121C, but not in I1112C.
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ABCC7 p.Ile1112Cys 23955087:123:219
status: NEW