ABCC7 p.Ile344Arg
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PMID: 23835419
[PubMed]
Loo TW et al: "Corrector VX-809 stabilizes the first transmembrane domain of CFTR."
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Sentence
Comment
168
Examples of the different effects of the arginines such as no effect (I344R), small reduction in maturation (V345R), large reduction in maturation (F337R), and no maturation (L346R) are shown in Fig. 4B. The TM6 arginine mutagenesis results were projected on a helical wheel (Fig. 4C).
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ABCC7 p.Ile344Arg 23835419:168:70
status: NEW178 Examples of typical results obtained with the I344R or M348R mutations introduced into V232D or H1085R are shown in Fig. 5B.
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ABCC7 p.Ile344Arg 23835419:178:46
status: NEW204 (B) Examples of immunoblots of wild-type CFTR and mutants I344R, V345R, F337R, and L346R showing the various effects of arginines introduced into TM6.
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ABCC7 p.Ile344Arg 23835419:204:58
status: NEW236 (B) Extracts of cells expressing wild-type CFTR or mutants V232D or H1085R with or without the I344R or M348R mutations were subjected to immunoblot analysis.
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ABCC7 p.Ile344Arg 23835419:236:95
status: NEW