ABCC7 p.Val345Arg
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PMID: 23835419
[PubMed]
Loo TW et al: "Corrector VX-809 stabilizes the first transmembrane domain of CFTR."
No.
Sentence
Comment
168
Examples of the different effects of the arginines such as no effect (I344R), small reduction in maturation (V345R), large reduction in maturation (F337R), and no maturation (L346R) are shown in Fig. 4B. The TM6 arginine mutagenesis results were projected on a helical wheel (Fig. 4C).
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ABCC7 p.Val345Arg 23835419:168:109
status: NEW204 (B) Examples of immunoblots of wild-type CFTR and mutants I344R, V345R, F337R, and L346R showing the various effects of arginines introduced into TM6.
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ABCC7 p.Val345Arg 23835419:204:65
status: NEW