ABCC7 p.Ile106Cys
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PMID: 23442957
[PubMed]
Gao X et al: "Cysteine scanning of CFTR's first transmembrane segment reveals its plausible roles in gating and permeation."
No.
Sentence
Comment
101
Fig. 3 A shows a continuous whole-cell recording of I106C-CFTR currents.
X
ABCC7 p.Ile106Cys 23442957:101:52
status: NEW105 Further addition of a specific CFTR inhibitor, CFTRinh-172 (39,40), caused a minor decrease of the residual current, indicating a drastic reduction of I106C-CFTR currents by external MTSES. Similar results were obtained for A107C- and Y109C-CFTR except that the magnitude of inhibition for A107C-CFTR is significantly smaller (Fig. 3 C).
X
ABCC7 p.Ile106Cys 23442957:105:151
status: NEW135 (A) A continuous recording of whole-cell I106C/Cysless channel current in response to an external application of MTSES.
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ABCC7 p.Ile106Cys 23442957:135:41
status: NEW263 (A) Representative single-channel traces for WT/Cysless, A96C/ Cysless, I106C/Cysless, and P99C mutant channels.
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ABCC7 p.Ile106Cys 23442957:263:72
status: NEW