ABCC7 p.Arg975Gln
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PMID: 17582383
[PubMed]
Melin P et al: "CFTR inhibition by glibenclamide requires a positive charge in cytoplasmic loop three."
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Sentence
Comment
4
Mutations of the neighbouring R975 (R975A, R975S, R975Q) did not affect electrophysiological and pharmacological properties of CFTR.
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ABCC7 p.Arg975Gln 17582383:4:50
status: NEW114 After expression in HEK-293 cells, the whole-cell chloride currents recorded with charge neutralizing mutants CFTR-R975A, R975Q and R975S (Fig. 5) showed similar electrophysiological properties as CFTR-wt: linear activation with Fsk, inhibition by glibenclamide and by CFTRinh-172.
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ABCC7 p.Arg975Gln 17582383:114:122
status: NEW153 (E) Current-voltage relationships normalized by cell capacitance recorded from R975A (n=11), R975S (n=7) and R975Q (n=4) EGFP-CFTR channels in presence of agonists.
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ABCC7 p.Arg975Gln 17582383:153:109
status: NEW