ABCA3 p.Asn53Gln
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PMID: 24142515
[PubMed]
Beers MF et al: "Disruption of N-linked glycosylation promotes proteasomal degradation of the human ATP-binding cassette transporter ABCA3."
No.
Sentence
Comment
47
The primers [primer nucleotide sequence is obtained from the National Center for Biotechnology (NCBI) of human ABCA3, data accession number NM_001089] generated for these mutant constructs are as follows: for N53Q: forward, 5=-tcggaaaatgtgccccaggccaccatctacccg-3=, reverse, 5=-cgggtagatggtggcctggggcacattttccga-3=; for N124Q: forward, 5=-ctacattaggtacgaccagtgctcgtccagcgtgc-3=, reverse, 5=-gcacgctggacgag- cactggtcgtacctaatgtag-3=; for N140Q, forward, 5=-tcgagcaccccttccagca- cagcaaggagcc-3=, reverse, 5=-ggctccttgctgtgctggaaggggtgctcga-3=, and for N945Q: forward, 5=-ccctcctggccatccagtactcctcggagct-3=, reverse, 5=- agctccgaggagtactggatggccaggaggg-3=.
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ABCA3 p.Asn53Gln 24142515:47:209
status: NEW153 As was observed in epithelial cell lines, immunoblot analysis of primary human AT2 cells revealed increased electrophoretic mobility of the primary translation products of single and double mutants of N124Q and N140Q but not the single mutant of N53Q (Fig. 7A).
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ABCA3 p.Asn53Gln 24142515:153:246
status: NEW