ABCG2 p.Lys86Ala
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PMID: 26294421
[PubMed]
Haider AJ et al: "Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences."
No.
Sentence
Comment
110
A further three control mutations were analysed, namely a substitution of lysine to alanine in the Walker-A motif (K86A), a substitution of glutamate to glutamine in the Walker-B motif (E211Q) and a substitution of asparagine to glutamine at the site of glycosylation (N596Q).
X
ABCG2 p.Lys86Ala 26294421:110:115
status: NEW155 These two mutants behaved in this assay in essentially the same way as the K86A and E211Q catalytically inactive mutants (result not shown).
X
ABCG2 p.Lys86Ala 26294421:155:75
status: NEW172 sfGFP-M549A and the catalytically inactive sfGFP-K86A isoform showed no Ko143-inhibited MX transport.
X
ABCG2 p.Lys86Ala 26294421:172:49
status: NEW173 With PhA, neither sfGFP-K86A nor sfGFP-M549A showed Ko143-inhibitable transport.
X
ABCG2 p.Lys86Ala 26294421:173:24
status: NEW