ABCG2 p.His155Ala
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PMID: 26136557
[PubMed]
Woodward OM et al: "ABCG2: the molecular mechanisms of urate secretion and gout."
No.
Sentence
Comment
51
Q141K Q141K / H155A 0.00 0.25 0.50 Q141K ABCG2 abundance relative to Wt Q141K ABCG2 H155A -- -- H155A GAPDH ABCG2 Wt ABCG2 Q141K H155 2 Q141K + H155A H155A ICL Q141K / Wt NBD B A C D ** Fig. 1.
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ABCG2 p.His155Ala 26136557:51:14
status: NEWX
ABCG2 p.His155Ala 26136557:51:84
status: NEWX
ABCG2 p.His155Ala 26136557:51:96
status: NEWX
ABCG2 p.His155Ala 26136557:51:144
status: NEWX
ABCG2 p.His155Ala 26136557:51:150
status: NEW55 C: biochemical confirmation of the model shows the Q141K mutant expression levels can be rescued with the secondary H155A substitution.
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ABCG2 p.His155Ala 26136557:55:116
status: NEW81 Replacing the histidine with an alanine appeared to resolve the shift and also significantly increased total Q141K (H155A) and mature, glycosylated protein abundance (Fig. 1, B-D) when expressed in HEK293 cells.
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ABCG2 p.His155Ala 26136557:81:116
status: NEW