ABCG2 p.Tyr459Ser
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PMID: 25445676
[PubMed]
Gal Z et al: "Mutations of the central tyrosines of putative cholesterol recognition amino acid consensus (CRAC) sequences modify folding, activity, and sterol-sensing of the human ABCG2 multidrug transporter."
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221
Tyr to Ser mutations at positions 459, 469 and 645 resulted in the loss of protein function, and the Tyr 459 to Ser mutation resulted in a complete loss of ABCG2 expression (Fig. 2).
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ABCG2 p.Tyr459Ser 25445676:221:101
status: NEW223 The fact that the Y459S mutant could not be expressed properly in insect cells suggests that the tyrosine at this amino acid position is crucial for the proper folding and processing of the protein and therefore might be an important determinant of ABCG2 structure.
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ABCG2 p.Tyr459Ser 25445676:223:18
status: NEW