ABCG2 p.Lys473Trp
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PMID: 23493553
[PubMed]
Woodward OM et al: "Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules."
No.
Sentence
Comment
89
Significantly, introduction of the K473W substitution on the Q141K background did not rescue total, mature, or dimer levels (all were actually significantly less) (Fig. 4 A-C and Fig. S5E).
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ABCG2 p.Lys473Trp 23493553:89:35
status: NEW90 The failure of the K473W mutation to rescue Q141K expression supports the hypothesis that the Q141K mutation does not interfere with interdomain interactions or dimerization of the ABCG2 protein.
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ABCG2 p.Lys473Trp 23493553:90:19
status: NEW134 Western blots of total (A) and dimer (B) expression of Q141K ABCG2 with secondary mutations at K473 demonstrating that K473W cannot rescue Q141K expression.
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ABCG2 p.Lys473Trp 23493553:134:119
status: NEW