ABCB3 p.Leu266Phe
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PMID: 26324772
[PubMed]
Geng J et al: "Use of Functional Polymorphisms To Elucidate the Peptide Binding Site of TAP Complexes."
No.
Sentence
Comment
129
As shown in the peptide transport analysis (Fig. 2A, 2B), rTAP1/TAP2a(Q262R), rTAP1/TAP2a(S265P), and rTAP1/TAP2a (L266F) displayed transport efficiencies quite similar to the wild-type rTAP1/TAP2a complex for both peptides.
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ABCB3 p.Leu266Phe 26324772:129:115
status: NEW133 To address whether other polymorphic rTAP2 residues have synergistic effects, we introduced a combination of four mutations within TM2 and TM3, which resulted in the quadruple mutant construct rTAP1/TAP2a (E218M/Q262R/S265P/L266F).
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ABCB3 p.Leu266Phe 26324772:133:224
status: NEW136 Similar results were obtained for the effects of the single (E218M) and quadruple (E218M/Q262R/S265P/L266F) mutations in rTAP2a upon transport of a pair of decapeptides, RYWANATK*SR (RR) and RYWANATK*SF (RF).
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ABCB3 p.Leu266Phe 26324772:136:101
status: NEW186 The quadruple mutant of rat TAP, TAP1/TAP2a(E218M/Q262R/ S265P/L266F), is indicated as EQSL/MPRF.
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ABCB3 p.Leu266Phe 26324772:186:63
status: NEW245 Binding of indicated TR (A) or TV (B) peptides to wild-type rTAP1/TAP2a (shown as WT), single mutant rTAP1/TAP2a(E218M) and quadruple mutant rTAP1/TAP2a(E218M/Q262R/S265P/L266F) (shown as EQSL/MRPF) was assessed using BMOE-mediated cross-linking assays, performed as described in Fig. 3.
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ABCB3 p.Leu266Phe 26324772:245:171
status: NEW