ABCB1 p.Glu1013Ala
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PMID: 25886173
[PubMed]
Golin J et al: "The multidrug transporter Pdr5 on the 25th anniversary of its discovery: an important model for the study of asymmetric ABC transporters."
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287
Gupta et al. [24] demonstrated further that replacement of multiple (Walker A, Walker B, and C-loop) deviant motifs with canonical ones in Pdr5 caused a significant loss, but not a complete elimination, of both ATPase and transport functions, rather reminiscent of the E1013A and D1042E phenotypes seen by Furman et al. [23].
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ABCB1 p.Glu1013Ala 25886173:287:269
status: NEW