ABCB3 p.Val656Ala
[switch to full view]Comments [show]
None has been submitted yet.
PMID: 25886173
[PubMed]
Golin J et al: "The multidrug transporter Pdr5 on the 25th anniversary of its discovery: an important model for the study of asymmetric ABC transporters."
No.
Sentence
Comment
161
Our group also constructed and tested a V656A mutant and showed that it was clearly signal-deficient.
X
ABCB3 p.Val656Ala 25886173:161:40
status: NEW163 The V656A mutant had a phenotype that was nearly identical with that of S558Y, including an ATPase that was reduced relative to WT, but markedly resistant to allosteric inhibition by clotrimazole (5-fold as resistant as the WT).
X
ABCB3 p.Val656Ala 25886173:163:4
status: NEW200 Therefore these mutants altered the stimulation signal, much like S558Y, V656L and V656A altered the trans-inhibition of Pdr5 ATPase by clotrimazole [18-20].
X
ABCB3 p.Val656Ala 25886173:200:83
status: NEW245 The mutant phenotype was therefore much like those of other signalling mutants, such as S558Y and V656A.
X
ABCB3 p.Val656Ala 25886173:245:98
status: NEW