ABCB1 p.Phe978Arg
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PMID: 26507655
[PubMed]
Loo TW et al: "Mapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein."
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Sentence
Comment
188
These were in TM7 (Q725R, F728R, and F732R) (Fig. 6A), TM10 (V865R, I868R, and G872R) (Fig. 6D), TM11 (F942R, T945R, Q946R, M949R, Y950R, and Y953R) (Fig. 6E), and TM12 (L975R, F978R, and V982R) (Fig. 6F).
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ABCB1 p.Phe978Arg 26507655:188:177
status: NEW194 The other 12 mutants in TM1 (F72R), TM5 (Y307R and Y310R), TM6 (F336R and F343R), TM7 (F732R), TM10 (V865R), TM11 (M949R, Y950R, S952R, and Y953R), and TM12 (L975R and F978R) were not rescued by cyclosporine A (Fig. 7).
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ABCB1 p.Phe978Arg 26507655:194:168
status: NEW213 Mutants L65R(TM1), A129R(TM2), F732R(TM7), Y950R(TM11), Y953R(TM11), and F978R- (TM12) showed partial activity (about 25-50% of wild-type activity), whereas the maximal tariquidar-stimulated ATPase activity of mutants H61R(TM1), G64R(TM1), F303R(TM5), F343R(TM6), Q725R(TM7), V865R(TM10, Q946R(TM11), and L975R(TM12) was about 50-100% of wild-type enzyme.
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ABCB1 p.Phe978Arg 26507655:213:73
status: NEW