ABCB1 p.Tyr444Phe
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PMID: 25987565
[PubMed]
Loo TW et al: "The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoprotein."
No.
Sentence
Comment
198
By contrast, the amount of mature P-gp in Y444F and Y1087F was similar to that of wild-type P-gp (Fig. 4A).
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ABCB1 p.Tyr444Phe 25987565:198:42
status: NEW207 Both the Y444F and Y444R mutants showed over 75% of wild-type activity.
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ABCB1 p.Tyr444Phe 25987565:207:9
status: NEW284 The presence of a hydroxyl group at position 444 was not essential however, as the Y444F mutant yielded wild-type levels of maturation and activity (Fig. 4).
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ABCB1 p.Tyr444Phe 25987565:284:83
status: NEW