ABCB1 p.Leu443Arg
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PMID: 25987565
[PubMed]
Loo TW et al: "The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoprotein."
No.
Sentence
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177
The amount of mature P-gp in mutants L443A, L443S, and L443F P-gps were similar to wild-type while mutant L443R yielded about 35% mature P-gp.
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ABCB1 p.Leu443Arg 25987565:177:106
status: NEW192 Asymmetry of the P-gp Drug Pump Transmission Interfaces 16958 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME 290ߦNUMBER 27ߦJULY 3, 2015 blocked verapamil stimulated ATPase activity, the L443A mutant resembled wild-type activity, and the L443R mutant retained about 35% activity (Fig. 4B).
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ABCB1 p.Leu443Arg 25987565:192:242
status: NEW212 The L443R and Y444R mutations only showed modest reductions (Fig. 4).
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ABCB1 p.Leu443Arg 25987565:212:4
status: NEW276 The F1086R or Y1087R mutations at the NBD2 socket blocked maturation and activity while P-gp showed substantial activity when the comparable mutations (L443R, Y444R) were made to the NBD1 socket.
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ABCB1 p.Leu443Arg 25987565:276:152
status: NEW