ABCB1 p.Leu443Ala
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PMID: 25987565
[PubMed]
Loo TW et al: "The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoprotein."
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Sentence
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177
The amount of mature P-gp in mutants L443A, L443S, and L443F P-gps were similar to wild-type while mutant L443R yielded about 35% mature P-gp.
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ABCB1 p.Leu443Ala 25987565:177:37
status: NEW192 Asymmetry of the P-gp Drug Pump Transmission Interfaces 16958 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME 290ߦNUMBER 27ߦJULY 3, 2015 blocked verapamil stimulated ATPase activity, the L443A mutant resembled wild-type activity, and the L443R mutant retained about 35% activity (Fig. 4B).
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ABCB1 p.Leu443Ala 25987565:192:191
status: NEW