ABCB1 p.Tyr790Ala
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PMID: 25987565
[PubMed]
Loo TW et al: "The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoprotein."
No.
Sentence
Comment
131
Mutants V907S (IH4) and Y790A (ICL3) represent examples of mutations that partially inhibited maturation.
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ABCB1 p.Tyr790Ala 25987565:131:24
status: NEW133 Mutation of Tyr-790 to alanine substantially reduced maturation as about 85% of the product was the 150 kDa immature protein.
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ABCB1 p.Tyr790Ala 25987565:133:12
status: NEW137 For example, the total P-gp yields in mutants R789A, V907S, Y790A, and V908S (Fig. 2A) were about 60, 75, 75, and 98% of wild-type P-gp, respectively.
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ABCB1 p.Tyr790Ala 25987565:137:60
status: NEW147 A, representative immunoblot of SDS extracts of whole cells transfected with wild-type P-gp (WT), control vector (Cont), or P-gp mutants R789A, V907S, Y790A, or V908S showing no maturation (R789A), partial maturation (V907S, Y790A) or maturation similar to wild-type P-gp (V908S).
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ABCB1 p.Tyr790Ala 25987565:147:151
status: NEWX
ABCB1 p.Tyr790Ala 25987565:147:225
status: NEW