ABCB10 p.Glu602Asp
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PMID: 25533467
[PubMed]
Kluth M et al: "A mutation within the extended X loop abolished substrate-induced ATPase activity of the human liver ATP-binding cassette (ABC) transporter MDR3."
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Comment
220
Oancea et al. (24) substituted the conserved glutamate (Glu-602) of the X loop of the transporter associated with antigen processing (TAP1/2) and demonstrated that peptide binding was not affected; however, transport activity was reduced from 20% for the E602D mutant to complete disruption for the E602R mutant, suggesting a pivotal role in transmitting conformational changes generated by ATP hydrolysis and substrate translocation.
X
ABCB10 p.Glu602Asp 25533467:220:255
status: NEW