ABCB1 p.Trp803Leu
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PMID: 24275649
[PubMed]
Loo TW et al: "Locking intracellular helices 2 and 3 together inactivates human P-glycoprotein."
No.
Sentence
Comment
106
Replacement of Trp803 with Leu, Ser, or Asp inhibited maturation, although all three mutants could still be rescued with cyclosporine A (Fig. 3, A and B).
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ABCB1 p.Trp803Leu 24275649:106:15
status: NEW132 A52-tagged mutants containing changes to Trp803 (A and B) (W803F (F), W803L (L), W803S (S), W803Y (Y), or W803D (D)) or Phe804 (CandD)(F804L(L),F804S(S),F804Y(Y),F804D(D),orF804W(W))were expressed in HEK 293 cells in the absence (afa;) or presence (af9;) of 5 òe;M cyclosporine A (Cyclo) for 18 h, and whole cell extracts were subjected to immunoblot analysis.
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ABCB1 p.Trp803Leu 24275649:132:70
status: NEW