ABCB1 p.Phe804Leu
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PMID: 24275649
[PubMed]
Loo TW et al: "Locking intracellular helices 2 and 3 together inactivates human P-glycoprotein."
No.
Sentence
Comment
104
The results are derived from three different transfections af9; S.D. Clamping IH2 to IH3 Inhibits P-gp JANUARY 3, 2014ߦVOLUME 289ߦNUMBER 1 JOURNAL OF BIOLOGICAL CHEMISTRY 231 at SEMMELWEIS UNIV OF MEDICINE on December 12, We then tested whether mutating Trp803 to Phe (hydrophobic), Leu (hydrophobic), Ser (hydrophilic), Tyr (aromatic), or Asp (charged) and Phe804 to Leu, Ser, Tyr, Asp, or Trp affected maturation of the protein.
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ABCB1 p.Phe804Leu 24275649:104:375
status: NEW109 Mutating Phe804 to Leu, Ser, or Asp inhibited maturation, and only the F804A or F804S mutants could be rescued with cyclosporine A to yield mature 170-kDa P-gp as the major product (Fig. 3, C and D).
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ABCB1 p.Phe804Leu 24275649:109:9
status: NEW