ABCB1 p.Phe804Tyr
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PMID: 24275649
[PubMed]
Loo TW et al: "Locking intracellular helices 2 and 3 together inactivates human P-glycoprotein."
No.
Sentence
Comment
104
The results are derived from three different transfections af9; S.D. Clamping IH2 to IH3 Inhibits P-gp JANUARY 3, 2014ߦVOLUME 289ߦNUMBER 1 JOURNAL OF BIOLOGICAL CHEMISTRY 231 at SEMMELWEIS UNIV OF MEDICINE on December 12, We then tested whether mutating Trp803 to Phe (hydrophobic), Leu (hydrophobic), Ser (hydrophilic), Tyr (aromatic), or Asp (charged) and Phe804 to Leu, Ser, Tyr, Asp, or Trp affected maturation of the protein.
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ABCB1 p.Phe804Tyr 24275649:104:375
status: NEW108 Mature 170-kDa P-gp was the major product in mutants F804Y and F804W (Fig. 3, C and D), although the amount of mature protein in the absence of cyclosporine A in mutant F804W was lower than in F804Y (65% versus 85%, respectively).
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ABCB1 p.Phe804Tyr 24275649:108:53
status: NEWX
ABCB1 p.Phe804Tyr 24275649:108:193
status: NEW