ABCB1 p.Trp803Phe
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PMID: 24275649
[PubMed]
Loo TW et al: "Locking intracellular helices 2 and 3 together inactivates human P-glycoprotein."
No.
Sentence
Comment
104
The results are derived from three different transfections af9; S.D. Clamping IH2 to IH3 Inhibits P-gp JANUARY 3, 2014ߦVOLUME 289ߦNUMBER 1 JOURNAL OF BIOLOGICAL CHEMISTRY 231 at SEMMELWEIS UNIV OF MEDICINE on December 12, We then tested whether mutating Trp803 to Phe (hydrophobic), Leu (hydrophobic), Ser (hydrophilic), Tyr (aromatic), or Asp (charged) and Phe804 to Leu, Ser, Tyr, Asp, or Trp affected maturation of the protein.
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ABCB1 p.Trp803Phe 24275649:104:271
status: NEW132 A52-tagged mutants containing changes to Trp803 (A and B) (W803F (F), W803L (L), W803S (S), W803Y (Y), or W803D (D)) or Phe804 (CandD)(F804L(L),F804S(S),F804Y(Y),F804D(D),orF804W(W))were expressed in HEK 293 cells in the absence (afa;) or presence (af9;) of 5 òe;M cyclosporine A (Cyclo) for 18 h, and whole cell extracts were subjected to immunoblot analysis.
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ABCB1 p.Trp803Phe 24275649:132:59
status: NEW