ABCB1 p.Ile297Arg
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PMID: 24083983
[PubMed]
Loo TW et al: "Drug rescue distinguishes between different structural models of human P-glycoprotein."
No.
Sentence
Comment
27
Examples of drug rescue of G251V and TM5 mutants G251V/I297R and G251V/S298R are shown in Figure 1B. When processing mutant G251V is expressed in the absence of cyclosporine A, the major product was the immature 150 kDa protein (~95% of total P-gp).
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ABCB1 p.Ile297Arg 24083983:27:55
status: NEW29 Mutant S298R but not I297R could be rescued by cyclosporine A.
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ABCB1 p.Ile297Arg 24083983:29:21
status: NEW