ABCB1 p.Phe1086Leu
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PMID: 23733192
[PubMed]
Loo TW et al: "Human P-glycoprotein contains a greasy ball-and-socket joint at the second transmission interface."
No.
Sentence
Comment
176
By contrast, those containing mutations of hydrophobic residues (F1086Y, F1086L, or F1086W) did not inhibit maturation.
X
ABCB1 p.Phe1086Leu 23733192:176:73
status: NEW
PMID: 24275649
[PubMed]
Loo TW et al: "Locking intracellular helices 2 and 3 together inactivates human P-glycoprotein."
No.
Sentence
Comment
151
These results show that maturation of P-gp was more sensitive to changes to Tyr1087 compared with Phe1086 because the F1086L mutation did not inhibit maturation (16).
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ABCB1 p.Phe1086Leu 24275649:151:118
status: NEW202 For example, mutation of Phe1086 to Leu, Phe, or Trp yielded P-gps with activities similar to the wild-type protein.
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ABCB1 p.Phe1086Leu 24275649:202:25
status: NEW
PMID: 25987565
[PubMed]
Loo TW et al: "The Transmission Interfaces Contribute Asymmetrically to the Assembly and Activity of Human P-glycoprotein."
No.
Sentence
Comment
178
Mutants F1086A, F1086L, and F1086W yielded mature 170 kDa protein as the major product, whereas F1086R yielded little mature P-gp (b0d;5%) (Fig. 4A).
X
ABCB1 p.Phe1086Leu 25987565:178:16
status: NEW